Neuropeptide Spray Comparator

The Semax and Selank Nasal Spray Comparator contains both peptides in nasal format, each bottle holding 10 mg across approximately 90 actuations. The labelled mass is the bottle total, not the per-spray content. Both peptides fall below 1,000 daltons, the molecular weight range where nasal absorption of peptides is most favourable.

Key Takeaways

• The comparator contains one Semax nasal spray and one Selank nasal spray, each with 10 mg across approximately 90 actuations.
• The labelled 10 mg describes the bottle total, not the content of a single actuation.
• Nominal per-actuation content, delivered content and absorbed content are three different figures, and each is smaller than the one before it.
• Nasal absorption of peptides falls sharply with molecular weight; Semax at approximately 813 daltons and Selank at approximately 751 daltons both fall in the most favourable range.
• Published nasal bioavailability figures generally describe systemic absorption, not the fraction reaching the central nervous system directly.
• Both products are supplied strictly for laboratory research and are not intended for human consumption, therapeutic use, veterinary use, or diagnostic applications.

What’s Included in This Comparator Set

Both are supplied as prepared solutions in nasal spray bottles with batch documentation. Confirm actuation count and molecular weight against the documentation supplied with your lot.

What “10 mg / 90 Sprays” Describes

The labelled mass is the bottle total

A bottle labelled 10 mg contains 10 mg in total, not 10 mg per actuation.

Divided across approximately 90 actuations, that gives roughly 111 micrograms per actuation nominally. The difference between those two figures is a factor of ninety, and the labelled figure is the one printed on the product — which is why it is frequently misread.

The same convention applies across nasal peptide products generally, and the same misreading recurs with them.

From bottle to absorbed: five different numbers

Nominal per-actuation content is not the end of the chain. Five distinct quantities sit between the label and what a study measures:

• Bottle total — the labelled figure, 10 mg.
• Nominal per actuation — bottle total divided by actuation count, approximately 111 µg.
• Actually delivered per actuation — lower than nominal. Priming consumes actuations, residual volume remains in the device, and delivery varies between actuations.
• Systemically absorbed — a fraction of what was delivered, strongly dependent on molecular weight.
• Reaching the central nervous system directly — a separate and considerably smaller fraction again.

Each step is smaller than the one before it, and the gap between the first and the last spans several orders of magnitude. Product specifications describe step one. Study designs generally care about step four or five.

Stating the chain matters because a specification figure is often treated as though it described exposure. It does not.