Mitochondrial Spray Pair

The Mitochondrial Nasal Spray Pair contains MOTS-c and SS-31 in nasal format, each bottle holding 10 mg across approximately 45 actuations. The two compounds fall in different nasal absorption ranges: SS-31, a tetrapeptide of roughly 640 daltons, sits in the most favourable range, while MOTS-c at roughly 2,174 daltons sits in a range where reported absorption is substantially lower.

Key Takeaways

• The pair contains one MOTS-c nasal spray and one SS-31 nasal spray, each with 10 mg across approximately 45 actuations.
• The labelled 10 mg describes the bottle total; nominal content per actuation is roughly 222 micrograms.
• SS-31 is a four-residue peptide of approximately 640 daltons and falls in the most favourable nasal absorption range.
• MOTS-c is a sixteen-residue peptide of approximately 2,174 daltons and falls in a range where reported nasal absorption is roughly an order of magnitude lower.
• The size difference is intrinsic to what each compound is, not a formulation choice, and cannot be changed.
• Both products are supplied strictly for laboratory research and are not intended for human consumption, therapeutic use, veterinary use, or diagnostic applications.

What’s Included in This Pair

Both are supplied as prepared solutions with batch documentation. Confirm actuation count and molecular weight against the documentation supplied with your lot.

What “10 mg / 45 Sprays” Describes

The labelled mass is the bottle total, not the content of a single actuation.

A 10 mg bottle delivering approximately 45 actuations contains roughly 222 micrograms per actuation nominally.

Nominal content is not delivered content — priming consumes actuations, residual volume remains in the device, and delivery varies between actuations. Delivered content is not absorbed content, which depends on absorption efficiency and, for this pair, differs substantially between the two compounds.

Each figure in that chain is smaller than the one before it, and the labelled bottle mass sits at the top.

These Two Compounds Are Not in the Same Absorption Band

Most nasal peptide pairings involve compounds of broadly similar size, and the format performs comparably for both. This pair does not work that way, and the difference is large enough to matter for study design.

Nasal absorption of peptides falls steeply with molecular size. Published work describes peptides below roughly 1,000 daltons absorbing far more efficiently than those in the 1,000 to 3,500 dalton range, where reported figures drop by roughly an order of magnitude, with further decline above that.

Where SS-31 sits

SS-31 is a four-residue peptide of approximately 640 daltons — one of the smallest compounds supplied in nasal format in this catalogue, and comfortably within the most favourable absorption range. On molecular weight grounds, SS-31 is a strong nasal candidate.

Where MOTS-c sits

MOTS-c is a sixteen-residue peptide of approximately 2,174 daltons, placing it in the intermediate range where reported nasal absorption is substantially lower than for smaller peptides.

MOTS-c is not among the more favourable nasal candidates on size grounds, and stating that is more useful than implying the format performs uniformly.