The Mitochondrial Nasal Spray Pair supplies MOTS-c and SS-31 in nasal format, each bottle containing 10 mg across approximately 45 actuations. The two compounds differ substantially in size — SS-31 is a tetrapeptide, MOTS-c a sixteen-residue peptide — which places them in different nasal absorption ranges. The format suits SS-31 considerably better on molecular weight grounds. For research use only.
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The Mitochondrial Nasal Spray Pair brings together two compounds studied in mitochondrial research, supplied in nasal format. Each bottle contains 10 mg across approximately 45 actuations, giving roughly 222 micrograms nominally per actuation — the labelled mass describes the bottle rather than the individual spray.
Molecular weight separates these two products in a way it does not separate most nasal pairs. SS-31 is a four-residue peptide of approximately 640 daltons, comfortably within the range where nasal absorption of peptides is most efficient. MOTS-c is a sixteen-residue peptide of approximately 2,174 daltons, which falls in a range where reported nasal absorption is roughly an order of magnitude lower.
The nasal format therefore suits one compound in this pair considerably better than the other, and that difference cannot be formulated away.
The size gap is not arbitrary. SS-31’s compact alternating structure is what enables it to concentrate at the inner mitochondrial membrane — it is small because it was designed to be. MOTS-c is encoded within mitochondrial DNA, and its length is a property of the sequence the mitochondrial genome carries. The size difference that separates the two compounds pharmacologically is the same difference that separates them in nasal format.
Researchers should note that SS-31, also known as elamipretide, received FDA approval in September 2025.
For Research Use Only. Not intended for human consumption, therapeutic use, veterinary use, or diagnostic applications.
The Mitochondrial Nasal Spray Pair contains MOTS-c and SS-31 in nasal format, each bottle holding 10 mg across approximately 45 actuations. The two compounds fall in different nasal absorption ranges: SS-31, a tetrapeptide of roughly 640 daltons, sits in the most favourable range, while MOTS-c at roughly 2,174 daltons sits in a range where reported absorption is substantially lower.
| Product | Peptide content | Actuations | Residues | Approximate MW |
|---|---|---|---|---|
| MOTS-c nasal spray | 10 mg per bottle | ~45 | 16 | ~2,174 Da |
| SS-31 nasal spray | 10 mg per bottle | ~45 | 4 | ~640 Da |
Both are supplied as prepared solutions with batch documentation. Confirm actuation count and molecular weight against the documentation supplied with your lot.
The labelled mass is the bottle total, not the content of a single actuation.
A 10 mg bottle delivering approximately 45 actuations contains roughly 222 micrograms per actuation nominally.
Nominal content is not delivered content — priming consumes actuations, residual volume remains in the device, and delivery varies between actuations. Delivered content is not absorbed content, which depends on absorption efficiency and, for this pair, differs substantially between the two compounds.
Each figure in that chain is smaller than the one before it, and the labelled bottle mass sits at the top.
Most nasal peptide pairings involve compounds of broadly similar size, and the format performs comparably for both. This pair does not work that way, and the difference is large enough to matter for study design.
Nasal absorption of peptides falls steeply with molecular size. Published work describes peptides below roughly 1,000 daltons absorbing far more efficiently than those in the 1,000 to 3,500 dalton range, where reported figures drop by roughly an order of magnitude, with further decline above that.
SS-31 is a four-residue peptide of approximately 640 daltons — one of the smallest compounds supplied in nasal format in this catalogue, and comfortably within the most favourable absorption range. On molecular weight grounds, SS-31 is a strong nasal candidate.
MOTS-c is a sixteen-residue peptide of approximately 2,174 daltons, placing it in the intermediate range where reported nasal absorption is substantially lower than for smaller peptides.
MOTS-c is not among the more favourable nasal candidates on size grounds, and stating that is more useful than implying the format performs uniformly.
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